Effects of exercise on brain and peripheral inflammatory biomarkers induced by total sleep deprivation in rats.

ABSTRACT: BACKGROUND:Physical exercise induces neuroprotection through anti-inflammatory effects and total sleep deprivation is reported an inflammatory process. We examined whether 7 weeks of exercise training attenuates markers of inflammation during total sleep deprivation (24-h wakefulness) in the rat brain and periphery. METHODS:Four groups of 10 rats were investigated: Sedentary control, Sedentary sleep-deprived, Exercised control, and Exercised sleep-deprived. Sleep deprivation and exercise training were induced using slowly rotating wheels and a motorized treadmill. We examined mRNA expression of pro-inflammatory (IL-1?, TNF-?, and IL-6) cytokine-related genes using real-time PCR, and protein levels in the hippocampus and frontal cortex, as well as circulating concentrations. RESULTS:Compared to Sedentary control rats, hippocampal and cortical IL-1? mRNA expressions in Sedentary sleep-deprived rats were up-regulated (p?

SUBMITTER: Chennaoui M 

PROVIDER: S-EPMC4588685 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature