Posttranscriptional deregulation of signaling pathways in meningioma subtypes by differential expression of miRNAs.

ABSTRACT:

Background

Micro (mi)RNAs are key regulators of gene expression and offer themselves as biomarkers for cancer development and progression. Meningioma is one of the most frequent primary intracranial tumors. As of yet, there are limited data on the role of miRNAs in meningioma of different histological subtypes and the affected signaling pathways.

Methods

In this study, we compared expression of 1205 miRNAs in different meningioma grades and histological subtypes using microarrays and independently validated deregulation of selected miRNAs with quantitative real-time PCR. Clinical utility of a subset of miRNAs as biomarkers for World Health Organization (WHO) grade II meningioma based on quantitative real-time data was tested. Potential targets of deregulated miRNAs were disc

SUBMITTER: Ludwig N 

PROVIDER: S-EPMC4588755 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature