The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936.

ABSTRACT:

Background

The DNA methylation-based 'epigenetic clock' correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability.

Methods

DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on chronological age) were estimated in the Lothian Birth Cohort 1936 at ages 70 (n = 920), 73 (n = 299) and 76 (n = 273) years. General cognitive ability, walking speed, lung function and grip strength were measured concurrently. Cross-sectional correlations between age acceleration and the fitness

SUBMITTER: Marioni RE 

PROVIDER: S-EPMC4588858 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature