Metabolic risk score and cancer risk: pooled analysis of seven cohorts.

ABSTRACT:

Background

There are few data on the joint influence of metabolic factors on risk of separate cancers.

Methods

We analysed data on body mass index, blood pressure and plasma levels of glucose, total cholesterol and triglycerides from seven European cohorts comprising 564 596 men and women with a mean age of 44 years. We weighted those factors equally into a standardized metabolic risk score [MRS, mean = 0, standard deviation (SD) = 1], with an individual's level indicated as SDs from the sex- and cohort-specific means. Cancer hazard ratios were calculated by Cox regression with age as timescale and with relevant adjustments including smoking status. All statistical tests were two-sided.

Results

During a mean follow-up of 12 years, 21 593 men and 14 348 women were diag

SUBMITTER: Stocks T 

PROVIDER: S-EPMC4588859 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature