DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring.

ABSTRACT: We examined whether the effect of maternal smoking during pregnancy on birthweight of the offspring was mediated by smoking-induced changes to DNA methylation in cord blood.First, we used cord blood of 129 Dutch children exposed to maternal smoking vs 126 unexposed to maternal and paternal smoking (53% male) participating in the GECKO Drenthe birth cohort. DNA methylation was measured using the Illumina HumanMethylation450 Beadchip. We performed an epigenome-wide association study for the association between maternal smoking and methylation followed by a mediation analysis of the top signals [false-discovery rate (FDR)?

SUBMITTER: Kupers LK 

PROVIDER: S-EPMC4588868 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature