<i>In vivo</i> tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity.

ABSTRACT: Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in inflammation, carcinogenesis and defense against infection. The cytotoxic activity of natural killer (NK) cells in TYK2-deficient (Tyk2^-/-) mice is severely reduced, although the underlying mechanisms are largely unknown. Using Tyk2^-/- mice and mice expressing a kinase-inactive version of TYK2 (Tyk2^K923E ), we show that NK cell function is partly independent of the enzymatic activity of TYK2. Tyk2^-/- and Tyk2^K923E NK cells develop normally in the bone marrow, but the maturation of splenic Tyk2^-/- NK cells (and to a lesser extent of Tyk2^K923E NK cells) is impaired. In

SUBMITTER: Prchal-Murphy M 

PROVIDER: S-EPMC4589058 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature