Deep sequencing analysis of transcriptomes in Aspergillus flavus in response to resveratrol.

ABSTRACT:

Background

Resveratrol has been reported as a natural phytoalexin that inhibits infection or the growth of certain fungi including Aspergillus flavus. Our previous research revealed that aflatoxin production in A. flavus was reduced in medium with resveratrol. To understand the molecular mechanism of the A. flavus response to resveratrol treatment, the high-throughput paired-end RNA-Seq was applied to analyze the transcriptomic profiles of A. flavus.

Results

In total, 366 and 87 genes of A. flavus were significantly up- and down- regulated, respectively, when the fungus was treated with resveratrol. Gene Ontology (GO) functional enrichment analysis revealed that 48 significantly differentially expressed genes were involved in 6 different terms. Most genes in the aflatoxin bi

SUBMITTER: Wang H 

PROVIDER: S-EPMC4589122 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature