Discovery of novel inhibitors for the treatment of glaucoma.

ABSTRACT:

Introduction

Glaucoma is a neurodegenerative disease with heterogeneous causes that result in retinal ganglionic cell (RGC) death. The discovery of ocular antihypertensives has shifted glaucoma therapy, largely, from surgery to medical intervention. Indeed, several intraocular pressure (IOP)-lowering drugs, with different mechanisms of action and RGC protective property, have been developed.

Areas covered

In this review, the authors discuss the main new class of kinase inhibitors used as glaucoma treatments, which lower IOP by enhancing drainage and/or lowering production of aqueous humor. The authors include novel inhibitors under preclinical evaluation and investigation for their anti-glaucoma treatment. Additionally, the authors look at treatments that are in clinics now

SUBMITTER: Cholkar K 

PROVIDER: S-EPMC4589152 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature