Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects Models.

ABSTRACT:

Context

Mathematical models may help the analysis of biological systems by providing estimates of otherwise un-measurable quantities such as concentrations and fluxes. The variability in such systems makes it difficult to translate individual characteristics to group behavior. Mixed effects models offer a tool to simultaneously assess individual and population behavior from experimental data. Lipoproteins and plasma lipids are key mediators for cardiovascular disease in metabolic disorders such as diabetes mellitus type 2. By the use of mathematical models and tracer experiments fluxes and production rates of lipoproteins may be estimated.

Results

We developed a mixed effects model to study lipoprotein kinetics in a data set of 15 healthy individuals and 15 patients with typ

SUBMITTER: Berglund M 

PROVIDER: S-EPMC4589417 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature