EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.

ABSTRACT: Advances in high-resolution cryo-electron microscopy (cryo-EM) require the development of validation metrics to independently assess map quality and model geometry. We report EMRinger, a tool that assesses the precise fitting of an atomic model into the map during refinement and shows how radiation damage alters scattering from negatively charged amino acids. EMRinger (https://github.com/fraser-lab/EMRinger) will be useful for monitoring progress in resolving and modeling high-resolution features in cryo-EM.

SUBMITTER: Barad BA 

PROVIDER: S-EPMC4589481 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature