Convergence in insulin resistance between very severely obese and lean women at the end of pregnancy.

ABSTRACT:

Aims

Disrupted intermediary metabolism may contribute to the adverse pregnancy outcomes in women with very severe obesity. Our aim was to study metabolism in such pregnancies.

Methods

We recruited a longitudinal cohort of very severely obese (n = 190) and lean (n = 118) glucose-tolerant women for anthropometric and metabolic measurements at early, mid and late gestation and postpartum. In case-control studies of very severely obese and lean women we measured glucose and glycerol turnover during low- and high-dose hyperinsulinaemic-euglycaemic clamps (HEC) at early and late pregnancy and in non-pregnant women (each n = 6-9) and body fat distribution by MRI in late pregnancy (n = 10/group).

Results

Although greater glucose, insulin, NEFA and insulin resistance (HOMA-IR)

SUBMITTER: Forbes S 

PROVIDER: S-EPMC4589551 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature