Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes.

ABSTRACT:

Aims/hypothesis

Upon tissue injury, peripheral sensory neurons release nociceptive factors (e.g. substance P [SP]), which exert local and systemic actions including the recruitment of bone marrow (BM)-derived haematopoietic stem and progenitor cells (HSPCs) endowed with paracrine pro-angiogenic properties. We herein explore whether diabetic neuropathy interferes with these phenomena.

Methods

We first investigated the presence of sensory neuropathy in the BM of patients with type 2 diabetes by immunohistochemistry and morphometry analyses of nerve size and density and assessment of SP release by ELISA. We next analysed the association of sensory neuropathy with altered HSPC release under ischaemia or following direct stimulation with granulocyte colony-stimulating factor (G-C

SUBMITTER: Dang Z 

PROVIDER: S-EPMC4589553 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature