The Set3 Complex Antagonizes the MYST Acetyltransferase Esa1 in the DNA Damage Response.

ABSTRACT: Acetylation is a dynamic posttranslational modification that contributes to chromatin-regulated processes, including DNA replication, repair, recombination, and gene expression. Acetylation is controlled by complexes containing opposing lysine and histone acetyltransferase (KAT and HAT) and deacetylase (KDAC and HDAC) activities. The essential MYST family Esa1 KAT acetylates core histones and many nonhistone substrates. Phenotypes of esa1 mutants include transcriptional silencing and activation defects, impaired growth at high temperatures, and sensitivity to DNA damage. The KDAC Rpd3 was previously identified as an activity opposing Esa1, as its deletion suppresses growth and silencing defects of esa1 mutants. However, loss of Rpd3 does not suppress esa1 DNA damage sensitivity. In this wo

SUBMITTER: Torres-Machorro AL 

PROVIDER: S-EPMC4589593 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature