Altered resting perfusion and functional connectivity of default mode network in youth with autism spectrum disorder.

ABSTRACT:

Background

Neuroimaging studies can shed light on the neurobiological underpinnings of autism spectrum disorders (ASD). Studies of the resting brain have shown both altered baseline metabolism from PET/SPECT and altered functional connectivity (FC) of intrinsic brain networks based on resting-state fMRI. To date, however, no study has investigated these two physiological parameters of resting brain function jointly, or explored the relationship between these measures and ASD symptom severity.

Methods

Here, we used pseudo-continuous arterial spin labeling with 3D background-suppressed GRASE to assess resting cerebral blood flow (CBF) and FC in 17 youth with ASD and 22 matched typically developing (TD) children.

Results

A pattern of altered resting perfusion was found i

SUBMITTER: Jann K 

PROVIDER: S-EPMC4589806 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature