Ontology highlight
ABSTRACT:
SUBMITTER: Nikpay M
PROVIDER: S-EPMC4589895 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20150907 10
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ...[more]