Ontology highlight
ABSTRACT:
SUBMITTER: Herranz N
PROVIDER: S-EPMC4589897 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Nature cell biology 20150817 9
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and contribute to age-related pathologies. In a drug screen to find new SASP regulators, we uncovered the mTOR inhibitor rapamycin as a potent SASP suppressor. Here we report a mechanism by which mTOR controls the SASP by differentially regulating t ...[more]