Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma.

ABSTRACT: Emerging evidence suggests pathological and immunoregulatory functions for IgG4 antibodies and IgG4⁺ B cells in inflammatory diseases and malignancies. We previously reported that IgG4 antibodies restrict activation of immune effector cell functions and impair humoral responses in melanoma. Here, we investigate IgG4 as a predictor of risk for disease progression in a study of human sera (n = 271: 167 melanoma patients; 104 healthy volunteers) and peripheral blood B cells (n = 71: 47 melanoma patients; 24 healthy volunteers). IgG4 (IgG4/IgG_total) serum levels were elevated in melanoma. High relative IgG4 levels negatively correlated with progression-free survival (PFS) and overall survival. In early stage (I-II) disease, serum IgG4 was independently negatively prognost

SUBMITTER: Karagiannis P 

PROVIDER: S-EPMC4590000 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature