Estrogen Receptor Alpha (ESR1) Gene Polymorphisms in Pre-eclamptic Saudi Patients.

ABSTRACT:

Objectives

Pre-eclampsia causes maternal mortality worldwide. Estrogen receptor alpha (ESR1) gene polymorphisms were responsible for cardiovascular diseases. This case control study was conducted to investigate whether 2 polymorphic genes of ESR1 are associated with pre-eclampsia among Saudi women in Madina city, Saudi Arabia.

Methods

Blood samples from 97 pre-eclamptic and 94 healthy pregnant women were analyzed using restriction fragment length polymorphism-polymerase chain reaction method. All the subjects were recruited randomly from outpatient clinics of Madina Maternity Children Hospital (MMCH), Madina, Saudi Arabia, between Dec. 2012 and Jan. 2014.

Results

There was no association between pre-eclampsia and PvuII and XbaI ESR1 gene polymorphisms individually. TT

SUBMITTER: El-Beshbishy HA 

PROVIDER: S-EPMC4590376 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature