Tissue growth controlled by geometric boundary conditions: a simple model recapitulating aspects of callus formation and bone healing.

ABSTRACT: The shape of tissues arises from a subtle interplay between biochemical driving forces, leading to cell growth, division and extracellular matrix formation, and the physical constraints of the surrounding environment, giving rise to mechanical signals for the cells. Despite the inherent complexity of such systems, much can still be learnt by treating tissues that constantly remodel as simple fluids. In this approach, remodelling relaxes all internal stresses except for the pressure which is counterbalanced by the surface stress. Our model is used to investigate how wettable substrates influence the stability of tissue nodules. It turns out for a growing tissue nodule in free space, the model predicts only two states: either the tissue shrinks and disappears, or it keeps growing indefinitel

SUBMITTER: Fischer FD 

PROVIDER: S-EPMC4590498 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature