Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.

ABSTRACT: Functional connectivity between brain regions relies on long-range signaling by myelinated axons. This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier. Although various potassium channel types have been anatomically localized to myelinated axons in the brain, direct evidence for their functional recruitment in maintaining node excitability is scarce. Cerebellar Purkinje cells provide continuous input to their targets in the cerebellar nuclei, reliably transmitting axonal spikes over a wide range of rates, requiring a constantly available pool of nodal sodium channels. We show that the recruitment of calcium-activated potassium channels (IK, K(Ca)3.1) by local, activity-dependent calcium (Ca(2+)) influx at no

SUBMITTER: Grundemann J 

PROVIDER: S-EPMC4590545 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature