Ontology highlight
ABSTRACT:
SUBMITTER: Grundemann J
PROVIDER: S-EPMC4590545 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Gründemann Jan J Clark Beverley A BA
Cell reports 20150903 11
Functional connectivity between brain regions relies on long-range signaling by myelinated axons. This is secured by saltatory action potential propagation that depends fundamentally on sodium channel availability at nodes of Ranvier. Although various potassium channel types have been anatomically localized to myelinated axons in the brain, direct evidence for their functional recruitment in maintaining node excitability is scarce. Cerebellar Purkinje cells provide continuous input to their targ ...[more]