Analysis of Environmental Chemical Mixtures and Non-Hodgkin Lymphoma Risk in the NCI-SEER NHL Study.

ABSTRACT:

Background

There are several suspected environmental risk factors for non-Hodgkin lymphoma (NHL). The associations between NHL and environmental chemical exposures have typically been evaluated for individual chemicals (i.e., one-by-one).

Objectives

We determined the association between a mixture of 27 correlated chemicals measured in house dust and NHL risk.

Methods

We conducted a population-based case-control study of NHL in four National Cancer Institute-Surveillance, Epidemiology, and End Results centers--Detroit, Michigan; Iowa; Los Angeles County, California; and Seattle, Washington--from 1998 to 2000. We used weighted quantile sum (WQS) regression to model the association of a mixture of chemicals and risk of NHL. The WQS index was a sum of weighted quartiles f

SUBMITTER: Czarnota J 

PROVIDER: S-EPMC4590749 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature