The correlation between the expression of differentiation markers in rat small intestinal mucosa and the transcript levels of schlafen 3.

ABSTRACT:

Importance

The normal absorptive function and structural maintenance of the intestinal mucosa depend on a constant process of proliferation of enterocytic stem cells followed by progressive differentiation toward a mature phenotype. The mechanisms that govern enterocytic differentiation in the mucosa of the small intestine are poorly understood.

Objective

To determine whether schlafen 3 (but not other schlafen proteins) act in vivo and whether its effects are limited to the small intestine. We have previously demonstrated in nonmalignant rat intestinal IEC-6 cells that schlafen 3 levels correlate with the expression of various differentiation markers in vitro in response to differentiation stimuli.

Design

Randomized controlled experiment.

Setting

Animal science

SUBMITTER: Kovalenko PL 

PROVIDER: S-EPMC4590985 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature