Medial frontal GABA is lower in older schizophrenia: a MEGA-PRESS with macromolecule suppression study.

ABSTRACT: Gamma-butyric acid (GABA) dysfunction has been implicated in the pathophysiology of schizophrenia and its cognitive deficits. Proton magnetic resonance spectroscopy (MRS) was used to test the hypothesis that older participants with schizophrenia have lower anterior cingulate GABA levels compared with older control participants. One-hundred forty-five participants completed this study. For detection of GABA, spectra were acquired from the medial frontal/anterior cingulate cortex using a macromolecule-suppressed MEGA-PRESS sequence. Patients were evaluated for psychopathology and all participants completed neuropsychological tests of working memory, processing speed and functional capacity. GABA levels were significantly lower in the older participants with schizophrenia (n=31) compared with

SUBMITTER: Rowland LM 

PROVIDER: S-EPMC4591074 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature