Does Apolipoprotein E Genotype Increase Risk of Postoperative Delirium?

ABSTRACT:

Objective

To determine whether apolipoprotein E (ApoE) is associated with postoperative delirium incidence, severity, and duration in older patients free of dementia at baseline.

Methods

The authors examined 557 nondemented patients aged 70 years or older undergoing major noncardiac surgery enrolled in the Successful Aging after Elective Surgery Study. Three ApoE measures were considered: ε2, ε4 carriers versus noncarriers, and a three-category ApoE measure. Delirium was determined using the Confusion Assessment Method (CAM) and chart review. We used generalized linear models to estimate the association between ApoE and delirium incidence, severity (peak CAM Severity [CAM-S] score), and days.

Results

ApoE ε2 and ε4 was present in 15% and 19%, respectively, and postope

SUBMITTER: Vasunilashorn S 

PROVIDER: S-EPMC4591079 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature