Factors Associated With Guideline-recommended KRAS Testing in Colorectal Cancer Patients: A Population-based Study.

ABSTRACT:

Objectives

Response to epidermal growth factor receptor inhibitors is poorer among stage IV colorectal cancer (CRC) patients with KRAS mutations; thus KRAS testing is recommended before treatment. KRAS testing was collected by Surveillance, Epidemiology, and End Results (SEER) registries for 2010 CRC cases, and our goal was to provide the first population-based estimates of testing in the United States.

Methods

SEER CRC cases diagnosed in 2010 were evaluated (n=30,351). χ tests and logistic regression were conducted to determine patient characteristics associated with KRAS testing, stratified by stages I-III versus stage IV. Log-rank tests were used to examine survival by testing status.

Results

KRAS testing among stage IV cases ranged from 39% in New Mexico to 15% in

SUBMITTER: Charlton ME 

PROVIDER: S-EPMC4591083 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature