Pharmacokinetics of intravenous sildenafil in children with palliated single ventricle heart defects: effect of elevated hepatic pressures.

ABSTRACT:

Unlabelled

Aims Sildenafil is frequently prescribed to children with single ventricle heart defects. These children have unique hepatic physiology with elevated hepatic pressures, which may alter drug pharmacokinetics. We sought to determine the impact of hepatic pressure on sildenafil pharmacokinetics in children with single ventricle heart defects.

Methods

A population pharmacokinetic model was developed using data from 20 single ventricle children receiving single-dose intravenous sildenafil during cardiac catheterisation. Non-linear mixed effect modelling was used for model development, and covariate effects were evaluated based on estimated precision and clinical significance.

Results

The analysis included a median (range) of 4 (2-5) pharmacokinetic samples per c

SUBMITTER: Hill KD 

PROVIDER: S-EPMC4591210 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature