Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate.

ABSTRACT: The prostate is a male accessory sex gland that produces secretions in seminal fluid to facilitate fertilization. Prostate secretory function is dependent on androgens, although the mechanism by which androgens exert their effects is still unclear. Polyamines are small cationic molecules that play pivotal roles in DNA transcription, translation and gene regulation. The rate-limiting enzyme in polyamine biosynthesis is ornithine decarboxylase, which is encoded by the gene Odc1. Ornithine decarboxylase mRNA decreases in the prostate upon castration and increases upon administration of androgens. Furthermore, testosterone administered to castrated male mice restores prostate secretory activity, whereas administering testosterone and the ornithine decarboxylase inhibitor D,L-α-difluromethylorn

SUBMITTER: Gamat M 

PROVIDER: S-EPMC4591331 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature