TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor.

ABSTRACT: Cold-sensitive nerve terminals (CSNTs) encode steady temperatures with regular, rhythmic temperature-dependent firing patterns that range from irregular tonic firing to regular bursting (static response). During abrupt temperature changes, CSNTs show a dynamic response, transiently increasing their firing frequency as temperature decreases and silencing when the temperature increases (dynamic response). To date, mathematical models that simulate the static response are based on two depolarizing/repolarizing pairs of membrane ionic conductance (slow and fast kinetics). However, these models fail to reproduce the dynamic response of CSNTs to rapid changes in temperature and notoriously they lack a specific cold-activated conductance such as the TRPM8 channel. We developed a model that includ

SUBMITTER: Olivares E 

PROVIDER: S-EPMC4591370 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature