Paradoxical association of lipoprotein measures with incident atrial fibrillation.

ABSTRACT:

Background

Low-density lipoprotein (LDL) cholesterol is a strong risk factor for atherosclerosis but has an inverse association with atrial fibrillation (AF). We aimed to provide insight into the paradoxical association of LDL cholesterol with AF by evaluating the relationship of various lipoprotein measures and incident AF.

Methods and results

We prospectively evaluated lipoprotein measures among 23 738 healthy middle-aged and older women (median follow-up 16.4 years; N=795 incident AF events). Baseline LDL cholesterol was directly measured, lipoprotein particle concentrations and size were measured by nuclear magnetic resonance spectroscopy, and apolipoproteins were measured by immunoassay. Cox regression models were adjusted for age, AF risk factors, inflammatory, and dys

SUBMITTER: Mora S 

PROVIDER: S-EPMC4591535 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature