Histone post-translational modifications in frontal cortex from human donors with Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the sixth leading cause of death and the most costly disease in the US. Despite the enormous impact of AD, there are no treatments that delay onset or stop disease progression currently on the market. This is partly due to the complexity of the disease and the largely unknown pathogenesis of sporadic AD, which accounts for the vast majority of cases. Epigenetics has been implicated as a critical component to AD pathology and a potential "hot spot" for treatments. Histone post-translational modifications (PTMs) are a key element in epigenetic regulation of gene expression and are known to be associated with the pathology of numerous diseases. Investigation of histone PTMs can help elucidate AD pathology and identify targets for therapies.

Re

SUBMITTER: Anderson KW 

PROVIDER: S-EPMC4591557 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature