Dietary lipids modulate the expression of miR-107, an miRNA that regulates the circadian system.

ABSTRACT:

Scope

The increased prevalence of cardiovascular diseases (CVDs) has been hypothesized to be the result of an increased exposure to a host of atherogenic environmental factors, paramount among them being unhealthy dietary habits. Long-chain n-3 polyunsaturated fatty acids have been shown to have cardio protective effects, partially due to their ability to regulate gene expression. In this regard, increasing attention has been devoted to the role of miRNAs as regulators of multiple metabolic pathways whose deregulation has been associated with CVD risk.

Methods and results

In this work, we investigated whether miRNA expression was regulated by docosahexanoic acid, conjugated linoleic acid, and cholesterol in Caco-2 cells. The modulated miRNAs, miR-107 was differentially expre

SUBMITTER: Daimiel-Ruiz L 

PROVIDER: S-EPMC4591752 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature