Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP.

ABSTRACT: The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to be controlled by cdG signaling. Although the biochemistry of cyclic dinucleotide metabolism is well understood, much remains to be discovered about the downstream signaling pathways that induce bacterial responses upon cdG binding. As part of our ongoing research into the role of cdG signaling in plant-associated Pseudomonas species, we carried out an affinity capture screen for cdG binding proteins in the model organism Pseudomonas fluorescens SBW25. The flagella export AAA+ ATPase FliI was identified as a result of this screen and subseq

SUBMITTER: Trampari E 

PROVIDER: S-EPMC4591828 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature