Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood.

ABSTRACT: With several therapeutic approaches in development for Huntington's disease, there is a need for easily accessible biomarkers to monitor disease progression and therapy response. We performed next-generation sequencing-based transcriptome analysis of total RNA from peripheral blood of 91 mutation carriers (27 presymptomatic and, 64 symptomatic) and 33 controls. Transcriptome analysis by DeepSAGE identified 167 genes significantly associated with clinical total motor score in Huntington's disease patients. Relative to previous studies, this yielded novel genes and confirmed previously identified genes, such as H2AFY, an overlap in results that has proven difficult in the past. Pathway analysis showed enrichment of genes of the immune system and target genes of miRNAs, which are downregulate

SUBMITTER: Mastrokolias A 

PROVIDER: S-EPMC4592077 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature