Mechanisms Underlying Mammalian Hybrid Sterility in Two Feline Interspecies Models.

ABSTRACT: The phenomenon of male sterility in interspecies hybrids has been observed for over a century, however, few genes influencing this recurrent phenotype have been identified. Genetic investigations have been primarily limited to a small number of model organisms, thus limiting our understanding of the underlying molecular basis of this well-documented "rule of speciation." We utilized two interspecies hybrid cat breeds in a genome-wide association study employing the Illumina 63 K single-nucleotide polymorphism array. Collectively, we identified eight autosomal genes/gene regions underlying associations with hybrid male sterility (HMS) involved in the function of the blood-testis barrier, gamete structural development, and transcriptional regulation. We also identified several candidate hybr

SUBMITTER: Davis BW 

PROVIDER: S-EPMC4592343 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature