Gene Expression Evolves under a House-of-Cards Model of Stabilizing Selection.

ABSTRACT: Divergence in gene regulation is hypothesized to underlie much of phenotypic evolution, but the role of natural selection in shaping the molecular phenotype of gene expression continues to be debated. To resolve the mode of gene expression, evolution requires accessible theoretical predictions for the effect of selection over long timescales. Evolutionary quantitative genetic models of phenotypic evolution can provide such predictions, yet those predictions depend on the underlying hypotheses about the distributions of mutational and selective effects that are notoriously difficult to disentangle. Here, we draw on diverse genomic data sets including expression profiles of natural genetic variation and mutation accumulation lines, empirical estimates of genomic mutation rates, and inference

SUBMITTER: Hodgins-Davis A 

PROVIDER: S-EPMC4592357 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature