Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.

ABSTRACT:

Purpose

Paclitaxel is used worldwide in the treatment of breast, lung, ovarian, and other cancers. Sensory peripheral neuropathy is an associated adverse effect that cannot be predicted, prevented, or mitigated. To better understand the contribution of germline genetic variation to paclitaxel-induced peripheral neuropathy, we undertook an integrative approach that combines genome-wide association study (GWAS) data generated from HapMap lymphoblastoid cell lines (LCL) and Asian patients.

Methods

GWAS was performed with paclitaxel-induced cytotoxicity generated in 363 LCLs and with paclitaxel-induced neuropathy from 145 Asian patients. A gene-based approach was used to identify overlapping genes and compare with a European clinical cohort of paclitaxel-induced neuropathy. Neur

SUBMITTER: Komatsu M 

PROVIDER: S-EPMC4592389 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature