Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma.

ABSTRACT:

Background

Although heregulin and human epidermal growth factor receptor 3 (HER3) are frequently expressed at high levels in patients with head and neck cancer, their prognostic value remains unclear. The authors explored the prognostic significance of heregulin/HER3 expression in patients with oropharyngeal squamous cell carcinoma (OPSCC), taking into account other HER family members as well as p16 status.

Methods

Ninety-six primary tumor specimens from patients with OPSCC were retrospectively collected and analyzed for heregulin messenger RNA (mRNA) using in situ hybridization and for HER3, epidermal growth factor receptor, and human epidermal growth factor receptor 2 (HER2) using quantitative immunohistochemistry. Heregulin and HER3 mRNA levels were also examined among di

SUBMITTER: Qian G 

PROVIDER: S-EPMC4592409 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature