Anal Cancer Incidence in the United States, 1977-2011: Distinct Patterns by Histology and Behavior.

ABSTRACT:

Background

Although anal squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are generally combined in cancer surveillance, their etiologies likely differ. Here, we describe demographic characteristics and trends in incidence rates (IR) of anal cancer by histology (SCC, ADC) and behavior (invasive, in situ) in the United States.

Methods

With data from the Surveillance, Epidemiology, and End Results (SEER) Program, we estimated age-adjusted anal cancer IRs across behavior/histology by demographic and tumor characteristics for 2000-2011. Trends in IRs and annual percent changes during 1977-2011 were also estimated and compared with rectal cancer.

Results

Women had higher rates of SCC [rate ratio (RR), 1.45; 95% confidence interval (CI), 1.40-1.50] and lower rates of

SUBMITTER: Shiels MS 

PROVIDER: S-EPMC4592448 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature