Prenatal Allogeneic Tolerance in Mice Remains Stable Despite Potent Viral Immune Activation.

ABSTRACT: Transplanting stem cells before birth offers an unparalleled opportunity to initiate corrective treatment for numerous childhood diseases with minimal or no host conditioning. Although long-term engraftment has been demonstrated following in utero hematopoietic cellular transplantation during immune quiescence, it is unclear if prenatal tolerance becomes unstable with immune activation such as during a viral syndrome. Using a murine model of in utero hematopoietic cellular transplantation, the impact of an infection with lymphocytic choriomeningitis virus on prenatal allospecific tolerance was examined. The findings in this report illustrate that established mechanisms of donor-specific tolerance are strained during potent immune activation. Specifically, a transient reversal in the anergy

SUBMITTER: Strong BS 

PROVIDER: S-EPMC4592829 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature