New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.

ABSTRACT: A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.

SUBMITTER: Dhimitruka I 

PROVIDER: S-EPMC4592842 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature