Glycated Albumin Levels in Patients with Type 2 Diabetes Increase Relative to HbA1c with Time.

ABSTRACT: We recently reported that glycated albumin (GA) is increased in subjects with longer duration of diabetes and with decreased insulin secretory function. Based on this, we investigated whether GA increases with time relative to glycated hemoglobin (HbA1c) and the association between GA and beta-cell function. We analyzed 340 type 2 diabetes patients whose serum GA and HbA1c levels had been repeatedly measured over 4 years. We assessed the pattern of changes with time in glycemic indices (GA, HbA1c, and GA/HbA1c ratio) and their relationship with beta-cell function. In all patients, glycemic indices decreased and maintained low levels around 15 and 27 months. However, from 39 months to 51 months, GA significantly increased but HbA1c tended to increase without statistical significance. We def

SUBMITTER: Yoon HJ 

PROVIDER: S-EPMC4592895 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature