Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization.

ABSTRACT: Pathologic ocular neovascularization commonly causes blindness. It is critical to identify the factors altered in pathologically proliferating versus normally quiescent vessels to develop effective targeted therapeutics. MicroRNAs regulate both physiological and pathological angiogenesis through modulating expression of gene targets at the posttranscriptional level. However, it is not completely understood if specific microRNAs are altered in pathologic ocular blood vessels, influencing vascular eye diseases. Here we investigated the potential role of a specific microRNA, miR-150, in regulating ocular neovascularization. We found that miR-150 was highly expressed in normal quiescent retinal blood vessels and significantly suppressed in pathologic neovessels in a mouse model of oxygen-induc

SUBMITTER: Liu CH 

PROVIDER: S-EPMC4593127 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature