Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth.

ABSTRACT:

Background

Preterm birth is the leading cause of mortality and morbidity in newborn infants. Its etiology is multifactorial with genes and environmental factors, including chronic maternal stress, contributing to its risk. Our objective was to investigate whether single nucleotide polymorphisms (SNPs) in genes involved in the stress response are associated with spontaneous preterm birth using a candidate gene approach.

Methods

A total of 210 cases (singleton spontaneous preterm birth at <37 weeks) and 412 controls (singleton term birth at 38-42 weeks without a history of preterm birth) were studied. High quality maternal DNA was available from saliva samples of 190 cases and 369 controls and compared. Sociodemographic and medical data were collected. Sixteen SNPs, either tag

SUBMITTER: Christiaens I 

PROVIDER: S-EPMC4593185 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature