Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue.

ABSTRACT: Weight loss has been shown to significantly improve Adipose tissue (AT) function, however changes in AT gene expression profiles particularly in visceral AT (VAT) have not been systematically studied. Here, we tested the hypothesis that extensive weight loss in response to bariatric surgery (BS) causes AT gene expression changes, which may affect energy and lipid metabolism, inflammation and secretory function of AT. We assessed gene expression changes by whole genome expression chips in AT samples obtained from six morbidly obese individuals, who underwent a two step BS strategy with sleeve gastrectomy as initial and a Roux-en-Y gastric bypass as second step surgery after 12 ± 2 months. Global gene expression differences in VAT and subcutaneous (S)AT were analyzed through the use of genom

SUBMITTER: Mardinoglu A 

PROVIDER: S-EPMC4593186 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature