Progesterone Receptor (PGR) gene polymorphism is associated with susceptibility to preterm birth.

ABSTRACT:

Background

Preterm birth (PTB) is the major cause of death in newborn and the second major cause of death in children less than 5 years old worldwide. Genetic polymorphism has been implicated as a factor for the occurrence of preterm birth. The aim of this study is to evaluate whether polymorphism in the progesterone receptor (PGR) is associated with susceptibility to preterm birth.

Methods

A total of 135 women with preterm and 532 women with term deliveries were genotyped for PGR gene polymorphisms (rs660149, rs471767, rs10895068) using Sequenom MassARRAY platform.

Results

The G allele of PGR rs660149 polymorphism was significantly associated with susceptibility to PTB in the Malay women. The odds of G allele occurring among Malay women with preterm delivery was twic

SUBMITTER: Langmia IM 

PROVIDER: S-EPMC4593226 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature