Aetiological role of common respiratory viruses in acute lower respiratory infections in children under five years: A systematic review and meta-analysis.

ABSTRACT:

Background

Acute lower respiratory infection (ALRI) remains a major cause of childhood hospitalization and mortality in young children and the causal attribution of respiratory viruses in the aetiology of ALRI is unclear. We aimed to quantify the absolute effects of these viral exposures.

Methods

We conducted a systematic literature review (across 7 databases) of case-control studies published from 1990 to 2014 which investigated the viral profile of 18592 children under 5 years with and without ALRI. We then computed a pooled odds ratio and virus-specific attributable fraction among the exposed of 8 common viruses - respiratory syncytial virus (RSV), influenza (IFV), parainfluenza (PIV), human metapneumovirus (MPV), adenovirus (AdV), rhinovirus (RV), bocavirus (BoV), and co

SUBMITTER: Shi T 

PROVIDER: S-EPMC4593292 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature