Cytokine-induced killer (CIK) cells: from basic research to clinical translation.

ABSTRACT: The accumulation of basic researches and clinical studies related to cytokine-induced killer (CIK) cells has confirmed their safety and feasibility in treating malignant diseases. This review summarizes the available published literature related to the biological characteristics and clinical applications of CIK cells in recent years. A number of clinical trials with CIK cells have been implemented during the progressive phases of cancer, presenting potential widespread applications of CIK cells for the future. Furthermore, this review briefly compares clinical applications of CIK cells with those of other adoptive immunotherapeutic cells. However, at present, there are no uniform criteria or large-scale preparations of CIK cells. The overall clinical response is difficult to evaluate becau

SUBMITTER: Guo Y 

PROVIDER: S-EPMC4593361 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature