Structural analysis of tumor-related single amino acid mutations in human MxA protein.

ABSTRACT:

Background

Human myxovirus resistant protein A (MxA), encoded by the myxovirus resistance 1 (Mx1) gene, is an interferon (IFN)-triggered dynamin-like multi-domain GTPase involved in innate immune responses against viral infections. Recent studies suggest that MxA is associated with several human cancers and may be a tumor suppressor and a promising biomarker for IFN therapy. Mx1 gene mutations in the coding region for MxA have been discovered in many types of cancer, suggesting potential biological associations between mutations in MxA protein and corresponding cancers. In this study, we performed a systematic analysis based on the crystal structures of MxA and elucidated how these mutations specifically affect the structure and therefore the function of MxA protein.

Methods

SUBMITTER: Hu JL 

PROVIDER: S-EPMC4593380 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature