TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Recent studies examining the association of Toll-like receptor 3 (TLR3) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on cancer risk.

Methods

We systematically reviewed studies that focused on a collection of 12 SNPs located in the TLR3 gene and the details by which these SNPs influenced cancer risk. Additionally, 14 case-control studies comprising a total of 7997 cases of cancer and 8699 controls were included in a meta-analysis of 4 highly studied SNPs (rs3775290, rs3775291, rs3775292, and rs5743312).

Results

The variant TLR3 genotype rs5743312 (C9948T, intron 3, C>T) was sign

SUBMITTER: Wang BG 

PROVIDER: S-EPMC4593388 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature