Enhancing neural stem cell response to SDF-1α gradients through hyaluronic acid-laminin hydrogels.

ABSTRACT: Traumatic brain injury (TBI) initiates an expansive biochemical insult that is largely responsible for the long-term dysfunction associated with TBI; however, current clinical treatments fall short of addressing these underlying sequelae. Pre-clinical investigations have used stem cell transplantation with moderate success, but are plagued by staggeringly low survival and engraftment rates (2-4%). As such, providing cell transplants with the means to better dynamically respond to injury-related signals within the transplant microenvironment may afford improved transplantation survival and engraftment rates. The chemokine stromal cell-derived factor-1α (SDF-1α) is a potent chemotactic signal that is readily present after TBI. In this study, we sought to develop a transplantation vehicle to

SUBMITTER: Addington CP 

PROVIDER: S-EPMC4593472 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature